Abstracts to publications by Rosetta Inpharmatics employees are available below. In some cases, supporting data is also available. Note: Current Rosetta Inpharmatics employees are shown in boldface type.

Johanna W. Lampe¹, Sergey B. Stepaniants², Mao Mao², Jerald P. Radich¹, Hongyue Dai², Peter S. Linsley², Stephen H. Friend² and John D. Potter¹

¹ Fred Hutchinson Cancer Research Center, Seattle, WA and
² Rosetta Inpharmatics, LLC, Merck Research Laboratories, Kirkland, WA

A microarray platform comparison for neuroscience applications.
J Neurosci Methods. 2004 Jan 15;132(1):57-68.

Mark L. Parrish^a, Nan Wei^b, Sven Duenwald^a, George Y. Tokiwa^a, Yanqun Wang^b, Daniel Holder^b, Hongyue Dai^a, Xiaohua Zhang^b, Christopher Wright^a, Paul Hodor^b, Guy Cavet^a, Robert L. Phillips^b, Benjamin I. Sun^b and Thomas L. Fare^a

^a Rosetta Inpharmatics LLC, a wholly owned subsidiary Merck & Co. Inc., 12040 115th Avenue NE, Kirkland, WA 98034, USA
^b Merck Research Laboratories, Merck & Co. Inc., Sumneytown Pike, West Point, PA 19486-0004, USA

Profiling of hepatic gene expression in rats treated with fibric acid analogs
Mutation Research 549 (2004) 131–145

Paul D. Cornwell., Angus T. De Souza, Roger G. Ulrich

Rosetta Inpharmatics-Merck Research Laboratories, 401 Terry Ave N, Seattle, WA 98109, USA

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes
Cell 2004 Jan 9 116(1) p.121-137

Pek Yee Lum,^1,6 Christopher D. Armour,^1,6 Sergey B. Stepaniants,¹ Guy Cavet,¹ Maria K. Wolf,³ J. Scott Butler,³ Jerald C. Hinshaw,⁵ Philippe Garnier,⁵ Glenn D. Prestwich,⁵ Amy Leonardson,1 Philip Garrett-Engele,¹ Christopher M. Rush,4 Martin Bard,⁴ Greg Schimmack,1 John W. Phillips,² Christopher J. Roberts,¹ and Daniel D. Shoemaker¹

¹Rosetta Inpharmatics LLC, a wholly-owned supsidiary of Merck & Co., Inc., 12040 115th Avenue N.E., Kirkland, WA 98034 USA
²Merck & Co., Inc., 126 East Lincoln Avenue, R80Y-255, Rahway, NJ 07065 USA
³Department of Microbiology and Immunology, J.P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 USA
⁴Department of Biology, Indiana University-Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202 USA
⁵Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108 USA

Johanna W. Lampe¹, Sergey B. Stepaniants², Mao Mao², Jerald P. Radich¹, Hongyue Dai², Peter S. Linsley², Stephen H. Friend² and John D. Potter<sup>1

1</sup> Fred Hutchinson Cancer Research Center, Seattle, WA and
² Rosetta Inpharmatics, LLC, Merck Research Laboratories, Kirkland, WA

Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression
Environ Health Perspect 2004 Mar 112(4) p.423-427

Roger G. Ulrich,¹ John C. Rockett,² G. Gordon Gibson,³ and Syril D. Pettit⁴

¹ Rosetta Inpharmatics, Merck Research Laboratories, Kirkland, Washington, USA;
² Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA;
³ Molecular Toxicology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, United Kingdom;
⁴ILSI Health and Environmental Sciences Institute, Washington, DC, USA

A resource for large-scale RNA-interference-based screens in mammals
Nature 2004 Mar 25 428(6981) p.427-431

Patrick J. Paddison¹,*, Jose M. Silva¹,*, Douglas S. Conklin¹,*,†, Mike Schilabach²,†, Mamie Li², Shola Aruleba1, Vivekanand Balija¹, Andy O'Shaughnessy¹, Lidia Gnoji¹, Kim Scobie¹, Kenneth Chang¹, Thomas Westbrook²,†, Michele Cleary³, Ravi Sachidandandam¹, W. Richard Mccombie¹, Stephen J. Elledge²,† & Gregory J. Hannon¹

¹ Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
² Department of Biochemistry, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
³ Rosetta Inpharmatics, 12040 115th Avenue NE, Kirkland, Washington 98034, USA
* These authors contributed equally to this work
† Present addresses: Department of Biomedical Sciences, Center for Functional Genomics, University at Albany, East Campus, B342A, One University Place, Rensselaer, New York 12144-2345, USA (D.S.C.); Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School Room 158D, NRB, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA (M.S., T.W. and S.J.E.)

A comprehensive transcript index of the human genome generated using microarrays and computational approaches
Genome Biol 2004 5(10) p.0-0

Eric E Schadt¹, Stephen W Edwards¹, Debraj GuhaThakurta¹, Dan Holder², Lisa Ying², Vladimir Svetnik², Amy Leonardson¹, Kyle W Hart³, Archie Russell¹, Guoya Li¹, Guy Cavet¹, John Castle¹, Paul McDonagh⁴, Zhengyan Kan¹, Ronghua Chen¹, Andrew Kasarskis¹, Mihai Margarint¹, Ramon M Caceres¹, Jason M Johnson¹, Christopher D Armour¹, Philip W Garrett-Engele¹, Nicholas F Tsinoremas⁵ and Daniel D Shoemaker¹

¹Rosetta Inpharmatics LLC, 12040 115th Avenue NE, Kirkland, WA 98034, USA
²Merck Research Laboratories, W42-213 Sumneytown Pike, POB 4, Westpoint, PA 19846, USA
³Rally Scientific, 41 Fayette Street, Suite 1, Watertown, MA 02472, USA
⁴Amgen Inc, 1201 Amgen Court W, Seattle, WA 98119, USA
⁵The Scripps Research Institute, Jupiter, FL 33458, USA

An integrative genomics approach to the reconstruction of gene networks in segregating populations
Cytogenet Genome Res 2004 105(4-Feb) p.363-374

J. Zhu^a, P. Y. Lum^a, J. Lamb^a, D. GuhaThakurta^a, S.W. Edwards^a, R. Thieringer^b, J.P. Berger^c, M.S. Wu^d, J. Thompson^e, A.B. Sachs^a, E.E. Schadt^a

^aRosetta Inpharmatics, Seattle, WA;
^bDepartment of Atherosclerosis and Endocrinology,
^cDepartment of Metabolic Disorders,
^dDepartment of Pharmacology,
^eDepartment of Molecular Profiling, Merck & Co, Rahway, NJ (USA)

Expression of alternatively spliced sodium channel alpha-supunit genes. Unique splicing patterns are observed in dorsal root ganglia
J Biol Chem 2004 Oct 29 279(44) p.46234-46241

Christopher K. Raymond, John Castle, Philip Garrett-Engele, Christopher D. Armour, Zhengyan Kan, Nicholas Tsinoremas, and Jason M. Johnson

 

Jerald P. Radich^a, ¹, Mao Mao^b, ¹, Sergey Stepaniants^b, ¹, Matt Biery^b, John Castle^b, Terry Ward^b, Greg Schimmack^b, Sumire Kobayashi^b, Michael Carleton^b, Johanna Lampe^a and Peter S. Linsley^b

^a Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109, USA
^b Rosetta Inpharmatics, Kirkland, WA 98034, USA
^*1 Supplementary data for this article may be found on ScienceDirect.
¹ These authors contributed equally to this work.

Exploration of essential gene functions via titratable promoter alleles
Cell 2004 Jul 9 118(1) p.31-44

Sanie Mnaimneh,^1,5 Armaity P. Davierwala,^1,5 Jennifer Haynes,^2,5 Jason Moffat,² Wen-Tao Peng,¹ Wen Zhang,^1,2 Xueqi Yang,¹ Jeff Pootoolal,¹ Gordon Chua,¹ Andres Lopez,¹ Miles Trochesset,¹ Darcy Morse,³ Nevan J. Krogan,^1,2 Shawna L. Hiley,¹ Zhijian Li,^1,2 Quaid Morris,¹ Jörg Grigull,¹ Nicholas Mitsakakis,¹ Christopher J. Roberts,⁴ Jack F. Greenblatt,^1,2 Charles Boone,^1,2 Chris A. Kaiser,³ Brenda J. Andrews,² and Timothy R. Hughes^1,2

¹Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, ON M5G 1L6, Canada
²Department of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, ON, Canada
³Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
⁴Rosetta Inpharmatics LLC, a wholly owned supsidiary of Merck & Co., Inc., 401 Terry Avenue North, Seattle, WA 98109 USA

 

Mao M, Biery MC, Kobayashi SV, Ward T, Schimmack G, Burchard J, Schelter JM, Dai H, He YD, Linsley PS

Noise amidst the silence: off-target effects of siRNAs?
Trends Genet 2004 Nov 20(11) p.521-524